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The peptide also does not stimulate IGF-1 production, avoiding the growth-promoting and potentially mitogenic effects associated with IGF-1 elevation

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However, FMT may alter the levels of both harmful and beneficial bacteria in the intestine, potentially leading to adverse effects (Khanna and Pardi, 2016)

no controlled trial has enrolled a general fitness or gym population for tesamorelin [5]

Astronauts with SANS had increased blood concentrations of metabolites within this pathway before and after LDSF (albeit the concentrations remained within the normal limits for the population) [68, 77]

Together, these findings highlight that while ACE-inhibitory peptides remain the most extensively studied, peptide-based strategies in cardiovascular diseases potentially extend beyond blood pressure regulation to include vascular repair, plaque stabilization, and endothelial modulation